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Volume 94 Issue 8 | p. 6 | News of The Week
Issue Date: February 22, 2016 | Web Date: February 17, 2016

DNA Enzymes Snip Amide Bonds

Biocatalysis: DNAs that hydrolyze amides could help with proteomic analyses
Department: Science & Technology
News Channels: Biological SCENE, JACS In C&EN, Organic SCENE
Keywords: catalysts, deoxyribozymes, DNA, amide hydrolysis

Chemists at the University of Illinois, Urbana-Champaign, have identified a deoxyribozyme that catalyzes amide hydrolysis, the first step toward making a DNA-based enzyme that can cleave proteins in specific places. Such a DNA enzyme could help researchers process proteins for proteomic studies.

Scott K. Silverman and his team have been trying unsuccessfully to find an amide-hydrolyzing deoxyribozyme for years. Their first attempt yielded a DNA that performed phosphodiester cleavage instead. “There’s something . . .

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Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society