Issue Date: February 22, 2016 | Web Date: February 17, 2016
DNA Enzymes Snip Amide Bonds
Chemists at the University of Illinois, Urbana-Champaign, have identified a deoxyribozyme that catalyzes amide hydrolysis, the first step toward making a DNA-based enzyme that can cleave proteins in specific places. Such a DNA enzyme could help researchers process proteins for proteomic studies.
Scott K. Silverman and his team have been trying unsuccessfully to find an amide-hydrolyzing deoxyribozyme for years. Their first attempt yielded a DNA that performed phosphodiester cleavage instead. “There’s something . . .
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