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Web Date: February 17, 2016

Enzyme Inhibitors Block Ebola

Medicinal Chemistry: Small-molecule enzyme inhibitors can stop Ebola virus from entering mouse cells
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: Ebola, virus, filovirus, cathepsins, enzyme inhibitor, small molecule drugs

The 2014 Ebola epidemic drew the world’s attention to the virus, which multiplies rapidly inside human tissues, destroying entire organs within days. Although antibodies have proved helpful in treating Ebola, no drugs block the virus. In many cases, all doctors can do is treat the symptoms and wait for the immune system to work. Now, researchers have engineered a group of small molecules that inhibit key cellular proteins, blocking Ebola’s ability to infect mouse cells . . .

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Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society