Volume 95 Issue 20 | p. 12 | News of The Week
Issue Date: May 15, 2017 | Web Date: May 10, 2017

New rules for Gram-negative antibiotics

Properties that allow compounds to get into and stay in Gram-negative bacteria could guide antibiotic discovery
Department: Science & Technology
Keywords: antibiotics, Gram-negative, drug discovery, bacteria

In the fight against pathogenic bacteria, Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa are particularly challenging foes.

These microbes don’t respond to many common antibiotics, and no new drug active against Gram-negative bacteria has been approved in nearly a half-century. Part of the difficulty in developing such antibiotics is that molecules have a hard time slipping inside Gram-negative bacteria. The bacteria have two cell membranes, and compounds must also navigate porin protein channels . . .

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