Issue Date: May 15, 2017 | Web Date: May 10, 2017
New rules for Gram-negative antibiotics
In the fight against pathogenic bacteria, Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa are particularly challenging foes.
These microbes don’t respond to many common antibiotics, and no new drug active against Gram-negative bacteria has been approved in nearly a half-century. Part of the difficulty in developing such antibiotics is that molecules have a hard time slipping inside Gram-negative bacteria. The bacteria have two cell membranes, and compounds must also navigate porin protein channels . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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