Volume 95 Issue 25 | pp. 28-33
Issue Date: June 19, 2017

Cover Story

How DNA-encoded libraries are revolutionizing drug discovery

With the bar-coding technology, drugmakers leverage the chemistry of large numbers
Department: Science & Technology
Keywords: nucleic acids, DNA-encoded library, drug discovery

Forty trillion is the kind of number that gives one pause. Consider it written out with its 13 zeros: 40,000,000,000,000. Assembling and maintaining a collection of 40 trillion of anything seems like a mind-bogglingly massive task. But in February the Danish biopharmaceutical company Nuevolution announced that it had created a library of 40 trillion unique molecules—quite possibly the largest collection of synthetic compounds in the world.

You might think it would require every . . .

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Chemical & Engineering News
ISSN 0009-2347
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