Volume 95 Issue 8 | p. 9 | News of The Week
Issue Date: February 20, 2017 | Web Date: February 16, 2017

New amination chemistry brought to light

Photogenerated radical cations yield amines previously impossible to make
Department: Science & Technology
News Channels: Organic SCENE
Keywords: synthesis, hydroamination, aminium radical action, anti-Markovnikov

Flashes of light help chemists at Princeton University and Bristol-Myers Squibb drive the hydroaminations of olefins to produce substituted amines. The light-powered reaction gives chemists another tool for installing amines in drugs and other biologically important molecules.

The new hydroamination is noteworthy for its intermolecular reactivity, its use of unactivated olefin substrates, its toleration of several different functional groups, and its regioselectivity for anti-Markovnikov amine products—wherein the new C–N bond forms on the less substituted . . .

To view the rest of this content, please log in with your ACS ID.



 
Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society