Volume 95 Issue 9 | p. 10 | Concentrates
Issue Date: February 27, 2017

Mode of action for unusual antibiotics found

Dithiolopyrrolones chelate metal ions, inhibiting cellular metalloenzymes
Department: Science & Technology
News Channels: Biological SCENE
Keywords: drug discovery, antibiotics, mechanism of action, metalloenzymes

Dithiolopyrrolones (DTPs) are disulfide-containing natural products with broad-spectrum antimicrobial activity. Studies have shown that DTPs inhibit several essential cellular processes, but their molecular mechanism has remained elusive. Bo Li of the University of North Carolina, Chapel Hill, and coworkers now find that a DTP called holomycin exerts its antibiotic activity by sequestering intracellular metal ions, particularly Zn2+ (Proc. Natl. Acad. Sci. USA 2017, DOI: 10.1073/pnas.1612810114). This . . .

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