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Copyright © 2013 American Chemical Society
March 4, 2013 Cover
Volume 91, Issue 9
Volume 91, Issue 9
Biotech firms rely on contract manufacturers for help and guidance on the road to market for new molecules
Credit: C&EN
» Full Article
March 4, 2013 Issue
Volume 91, Issue 9
March 4, 2013 Issue, Vol. 91 | Iss. 9
Biotech firms rely on contract manufacturers for help and guidance on the road to market for new molecules
(p.15)
Features
Science & Technology
Chemists debate the best way to use reaction data to compare catalyst efficiencies (pp. 46-47)
Science & Technology
A potpourri of analytical techniques reveals purported Aztec sculptures are not bona fide (pp. 48-49)
Cover Story: Turning Ideas Into Drugs
Long-Term Partners
Case Study #2: A decadelong relationship is poised to yield a second polymeric drug
(pp. 18-19)Helping Tie Up A Peptide Drug’s Loose Ends
Case Study #1: Ironwood works with peptide makers and others to turn its cross-linked molecule into a drug
(pp. 16-17)An Orphan Gets Help
Case Study #3: A race by partners turns an unsuccessful cholesterol drug into a treatment for a rare disorder
(pp. 20-21)News of the Week
Cool Way To Make Hydrogen From Methanol
Fuel Chemistry: Soluble ruthenium catalyst could drop operating temperatures of fuel cells
(p.9)China Steps Up Toxin Controls
Environment: New action plan acknowledges the presence of cancer clusters
(p.10)Federal Open-Access Mandate
Publishing: White House directs agencies to provide free access to results of taxpayer-funded research
(p.10)Bayer And BASF Post Record Sales In 2012
Growth: But net earnings dip at the German chemical giants
(p.11)River Blindness Marker Found In Patients
Diagnostics: Discovery of parasite-derived metabolite could aid effort to wipe out tropical disease
(p.11)Toward Silicon Metathesis
Organometallics: Chemists achieve key steps in quest for a silicon version of classic synthesis
(p.12)White House Aims At Trade Secret Theft
Intellectual Property: Administration’s new strategy has chemical industry support
(p.12)Dual-Use Research Policies Issued
Biosecurity: Research on avian flu viruses and other pathogens to receive higher level of scrutiny
(p.13)Royalty Pharma Targets Elan
Buy Proposal: Drug firm scoffs at offer, plans to reinvest coming windfall
(p.13)Departments
Business
Case Study #2: A decadelong relationship is poised to yield a second polymeric drug
(pp. 18-19)
Patent losses on many top-selling drugs caused declines in both sales and earnings
(pp. 34-37)
Case Study #1: Ironwood works with peptide makers and others to turn its cross-linked molecule into a drug
(pp. 16-17)
Case Study #3: A race by partners turns an unsuccessful cholesterol drug into a treatment for a rare disorder
(pp. 20-21)
Fourth-quarter chemical earnings increase as the industry learns to boost profit margins even as sales stagnate
(pp. 30-33)
Biotech firms rely on contract manufacturers for help and guidance on the road to market for new molecules
(p.15)
Money and accomplished scientists boost efforts to build world-class pharmaceutical institutes
(pp. 24-28)Concentrates
(pp. 22-23)
(pp. 22-23)- Evonik Set For IPO … Again
- Ascend Eyes New Propylene Facility
- Wacker Invests In Battery Company
- Evonik Completes Recovery From Fire …
- … Plans Cyanide Plant With Mexican Partner
- University Of Manchester Signs With IP Group
- Sekisui And Lubrizol Set Up Thai Venture
- Elementis Adds Hi-Mar Additives Business
- BASF And Bend To Develop Excipients
- Shimadzu Donates To UT Arlington
- Takeda And Affymax Recall Anemia Drug
- UCB Signs Pacts In Neuroscience
- LEO Pharma, 4SC Ink Dermatology Deal
- Business Roundup
ACS News
More than 17,000 attendees will convene at this annual conference and exposition on lab science
(pp. 64-65)Awards(pp. 57-63)
(pp. 57-63)- 2013 ACS National Award Winners
- Arthur C. Cope Award Winner: Stephen L. Buchwald
- Arthur C. Cope Scholar: William R. Dichtel
- Arthur C. Cope Scholar: Makoto Fujita
- Arthur C. Cope Scholar: Michael J. Krische
- Arthur C. Cope Scholar: Donald S. Matteson
- Arthur C. Cope Scholar: Bradley S. Moore
- Arthur C. Cope Scholar: Thomas W. Muir
- Arthur C. Cope Scholar: Jack R. Norton
- Arthur C. Cope Scholar: Sarah E. Reisman
- Arthur C. Cope Scholar: Martin F. Semmelhack
- Arthur C. Cope Scholar: Shannon S. Stahl
Government & Policy
Science advisers to suggest improvements for work on computational toxicology, cost estimates of regulations
(p.40)
Chemists add to AAAS coalition on intersection of science and human rights
(pp. 41-42)
Some 30 lawmakers come together to advocate for science funding, raise awareness about the role of basic research in economic growth
(p.43)Books
Pesticide introduced in the 1940s has played a significant role in U.S. history
(pp. 54-55)Education
Community lauds ACS report on improving graduate education in chemistry but doubts the feasibility of many recommendations
(pp. 51-53)
Science & Technology
Chemists debate the best way to use reaction data to compare catalyst efficiencies
(pp. 46-47)
A potpourri of analytical techniques reveals purported Aztec sculptures are not bona fide
(pp. 48-49)Concentrates(pp. 44-45)
(pp. 44-45)- Healthy Fruit Skin
- Composite Catalyst For Chiral Synthesis
- Carbon Aerogels Sop Up Hydrocarbons
- Mercury In Fluorescent Bulbs Has A Unique Isotope Fingerprint
- Elusive Alkynylation Achieved
- Molecular Velcro Is Sticky When Wet
- Chemists Build Synthetic Polymers From A DNA Blueprint
- Self-Assembly Gives Anticancer Drug An Edge