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Copyright © 2013 American Chemical Society
March 25, 2013 Cover
Volume 91, Issue 12
Volume 91, Issue 12
It helps millions with bipolar disorder, but toxicity problems and side effects have scientists looking for alternatives by analyzing the drug’s mysterious mechanism
Credit: Getty Images/Shutterstock/C&EN
» Full Article
March 25, 2013 Issue
Volume 91, Issue 12
March 25, 2013 Issue, Vol. 91 | Iss. 12
It helps millions with bipolar disorder, but toxicity problems and side effects have scientists looking for alternatives by analyzing the drug’s mysterious mechanism
(pp. 15-20)
Features
Government & Policy
Stakeholders seek to reduce the amount of pesticide-contaminated dust generated during corn planting (pp. 30-31)
Science & Technology
Changes in ocean chemistry threaten Washington state’s Makah tribe as well as the region’s shellfish industry (pp. 36-37)
News of the Week
AstraZeneca’s Lean New Look
Big Pharma: Thousands of job cuts and emphasis on three R&D areas highlight CEO Pascal Soriot’s revival strategy
(p.9)Dow Plans More U.S. Investment
Shale Gas: Chemical maker discloses plans for Gulf Coast polymer facilities
(p.10)Hydrogels Take Multiple Shapes
Materials: Gel sheets adopt 3-D forms in response to various stimuli
(p.10)Avoiding The Death Receptor
Biochemistry: Crystal structures of serotonin receptor-drug complexes could reduce killer side-effects
(p.11)A Vision For Bionic Retinas
Bioelectronics: Polymeric device restores light sensitivity to damaged retinas removed from rats
(p.12)Instrument Executives At Pittcon See A Spotty Outlook
Caution is the watchword among scientific toolmakers at the Philadelphia meeting
(p.12)Insecurity About Chemical Plants
Facilities: Federal officials defend backlogged risk-assessment program
(p.13)Departments
Business
Improving on biologic drugs is an alternative to taking a more generic route
(pp. 24-25)
German chemical maker establishes its China venture in a little-known northern city
(pp. 26-27)Concentrates
(pp. 22-23)
(pp. 22-23)- Solar Installations Hit Record Numbers
- Three Partners Plan Saudi Phosphate Plant
- Lubrizol Invests Big In Specialty Polymer
- AkzoNobel Revamps An Operation In China
- Ecover Packaging To Use Ocean Trash
- Italy’s Italmatch Buys Phosphorus Businesses
- Biobased Materials Head Toward Market
- DSM Acquires Light-Trapping Technology
- BASF Focuses Leather, Textile Businesses
- Perstorp, Purac Eye Biobased Copolymers
- NPS Regains Global Rights To Gattex
- Biotech Firm Gets Merck Inhibitors
- Affymax Cuts Jobs After Drug Setback
- Business Roundup
ACS News
Candidate selections and petitions are on the agenda for the spring ACS national meeting in New Orleans
(p.50)
Through its annual poster contest, the ACS Southern Nevada Section inspires high school students to explore the power of chemistry
(pp. 48-49)
Government & Policy
Stakeholders seek to reduce the amount of pesticide-contaminated dust generated during corn planting
(pp. 30-31)
Policy meant to rein in federal spending may increase costs, stifle scientific progress, critics say
(pp. 32-33)Books
Former vice president maintains that six interacting megatrends will determine humanity’s fate on Earth
(pp. 44-45)Education
Professors shift lectures online to free up class time for more effective learning activities
(pp. 41-43)
Science & Technology
Changes in ocean chemistry threaten Washington state’s Makah tribe as well as the region’s shellfish industry
(pp. 36-37)
It helps millions with bipolar disorder, but toxicity problems and side effects have scientists looking for alternatives by analyzing the drug’s mysterious mechanism
(pp. 15-20)
Chemists from around the world gather to fete the German Chemical Society’s premier publication
(pp. 38-40)Concentrates(pp. 34-35)
(pp. 34-35)- DNA Weaved Into A Gridiron
- Drug To Fight Both Indigestion And Pain
- Struggles With Fracking Wastewater
- Nanocalipers Get A Grip On Nanotubes
- New Molecular Weapon Against Malaria
- Ionic Liquid Helps Recycle Rare Earths
- Chinese Herbal Medicine Compounds May Not Be Clues To Diabetes Treatments After All
- Single Molecules Imaged In Living Mammalian Cell Nuclei