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Global Health

Gilead and Merck collaborate on combo HIV treatment

by Lisa M. Jarvis
March 20, 2021 | A version of this story appeared in Volume 99, Issue 10

 

The structure of islatravir.

Gilead Sciences and Merck & Co. will collaborate to develop a long-acting HIV treatment that combines Gilead’s capsid inhibitor lenacapavir with Merck’s islatravir, a nucleoside reverse transcriptase translocation inhibitor. The molecules are being studied separately in late-stage trials to treat or prevent HIV. Both have long half-lives and robust virus-suppressing activity at low doses. The goal is to replace the daily regimen of pills taken by people with HIV with one pill that is taken every few months.

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