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Volume 88 Issue 11 | p. 48 | Concentrates
Issue Date: March 15, 2010

New Method Flags Protein Acetylation

Alkyne analogs of acetyl-CoA deliver a faster, safer method to ID acetylated proteins for biological studies
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: click chemistry, posttranslational modification, protein analysis

Acetylation of lysine residues in proteins plays a key role in modulating biological activities. For example, acetylation of histones, the protein spools for DNA in cells, helps regulate gene expression. Acetylation is typically detected by radiolabeling techniques, but researchers at Rockefeller University are now reporting a faster, safer method for identifying proteins that undergo this posttranslational modification (J. Am. Chem. Soc., DOI: 10.1021/ja908871t). Yu-Ying Yang, Janice M. Ascano, and Howard C. . . .

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