ACS Meeting News: Reagent Assembles Ring Motifs Common In Drugs | March 24, 2014 Issue - Vol. 92 Issue 12 | Chemical & Engineering News
 
 
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Volume 92 Issue 12 | p. 6 | News of The Week
Issue Date: March 24, 2014 | Web Date: March 20, 2014

ACS Meeting News: Reagent Assembles Ring Motifs Common In Drugs

Method builds medium-sized nitrogen heterocycles with challenging substitution patterns
Department: Science & Technology
News Channels: Organic SCENE
Keywords: organometallic chemistry, heterocycles, medicinal chemistry, tin

Saturated heterocycles such as piperidines and morpholines are common in bioactive molecules, so drugmakers would like to have straightforward ways to incorporate them into their molecular collections. However, these rings tend to be difficult to append to molecular scaffolds, requiring laborious multistep protocols in many cases.

In contrast, chemists snap aromatic rings together with ease using metal-catalyzed cross-coupling reactions. Researchers have attempted to develop cross-couplings that work on saturated heterocycles, but they aren’t yet broadly . . .

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