Volume 93 Issue 35 | p. 33 | Concentrates
Issue Date: September 7, 2015

DNA ‘Yarn Balls’ Deliver Biomolecules

Web: Yarn-ball-like DNA Nanoparticles Deliver Biomolecules for CRISPR Technique
Department: Science & Technology | Collection: Life Sciences
News Channels: Materials SCENE, Nano SCENE
Keywords: CRISPR, Cas9, DNA, nanoparticle

Biotechnology companies are becoming increasingly fixated with the genome-editing technique known as CRISPR/Cas9 (see page 14). For this potentially therapeutic technology to safely and selectively alter genes of living cells, scientists need to develop reliable methods to shuttle biomolecules into cell nuclei to edit genetic material. Researchers from the University of North Carolina, Chapel Hill, and North Carolina State University have now developed DNA nanoparticles that effectively deliver DNA-cleaving Cas9 proteins to their target (Angew. . . .

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