Issue Date: July 4, 2016
Deuterium switcheroo breathes life into old drugs
Heavier than hydrogen by a single neutron, deuterium might not seem to have much chemical heft. But the small matter of that subatomic particle makes a massive difference in the reactivity of hydrogen versus its isotope deuterium.
In particular, deuterium can be far more difficult to pluck from a carbon atom than hydrogen. That property has long intrigued drugmakers: Metabolic enzymes often begin to break down drugs by stripping them of their hydrogen atoms. If . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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