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Copyright © 2013 American Chemical Society
January 21, 2013 Cover
Volume 91, Issue 3
Volume 91, Issue 3
Subtherapeutic doses in drug development tests have shown important—but unanticipated—advantages
Credit: Shutterstock/Yang H. Ku/C&EN
» Full Article
January 21, 2013 Issue
Volume 91, Issue 3
January 21, 2013 Issue, Vol. 91 | Iss. 3
Subtherapeutic doses in drug development tests have shown important—but unanticipated—advantages
(pp. 9-13)
Features
Science & Technology
Tetsuo Nozoe’s newly published collection of chemists’ signatures and structures showcases 41 years of vital science (pp. 28-29)
News of the Week
Global-Warming Warnings
Climate: Reports concur that human-induced changes are already leading to damaging environmental shifts
(p.4)AstraZeneca’s R&D Overhaul
Pharmaceuticals: Research head Martin Mackay is out in leadership shake-up
(p.5)Chemical Treatment Alleviates Nanotube Toxicity
Safety: Hydrophilic modifications render asbestos-like nanotube bundles harmless in mice
(p.5)Energy Department Announces Radioactive Waste Strategy
Nuclear: Plan calls for interim storage site by 2021, geologic repository by 2048
(p.6)Polysilicon Makers Cut Production, Lay Off Workers
Solar glut: Low prices and tariff threats force reduction in raw material manufacturing
(p.6)Faster Membrane Gas Separations
Industrial: New polymer membranes lock in porosity, enhancing selectivity and permeability
(p.7)Fiscal 2014 Federal Budget Delayed
Amid a stew of fiscal issues, the White House says rollout of spending plan will be delayed
(p.7)Cubelike DNA Visualized In Cells
Drug Discovery: Elusive drug targets called G-quadruplexes confirmed in human DNA
(p.8)M&G Picks Sinopec To Build Polyester Plant
Billion dollar project in Texas unites several foreign partners
(p.8)Departments
Business
Unusual deal is a diversification move for growing California firm
(p.18)
California firm values independence as it flaunts its technical competence
(pp. 16-17)Concentrates
(pp. 14-15)
(pp. 14-15)- PPG Ponders Future Of Transitions Optical
- Vietnam Refinery Plan Moves Forward
- Evonik Invests In Capacity, Cleantech
- Clariant, Croda Buy Ingredients Makers
- BASF Boosts Offer For Pronova
- Pemex Approves Vinyl Chloride Unit
- Renmatix Starts Up Research Unit
- Oil-Field Chemical Firm Aegis Acquired
- AstraZeneca Licenses Vanderbilt Compounds
- Almac Adds Pharma Development Capacity
- Accelrys Buys Swiss Systems Integrator
- Xylem Lands NASA Instrument Contract
- Business Roundup
Science & Technology
Tetsuo Nozoe’s newly published collection of chemists’ signatures and structures showcases 41 years of vital science
(pp. 28-29)
Subtherapeutic doses in drug development tests have shown important—but unanticipated—advantages
(pp. 9-13)
Researchers reveal troubling practices and perceptions in laboratories
(pp. 30-31)