Advertisement
Grab your lab coat. Let's get started
Welcome!
Welcome!
Create an account below to get 6 C&EN articles per month, receive newsletters and more - all free.
It seems this is your first time logging in online. Please enter the following information to continue.
As an ACS member you automatically get access to this site. All we need is few more details to create your reading experience.
Not you? Sign in with a different account.
Not you? Sign in with a different account.
ERROR 1
ERROR 1
ERROR 2
ERROR 2
ERROR 2
ERROR 2
ERROR 2
Password and Confirm password must match.
If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)
ERROR 2
ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.
Synthesis
Twisted amides
September 25, 2006
| A version of this story appeared in
Volume 84, Issue 39
While I really loved the elegant chemistry highlighted in Bethany Halford's article titled "Amide with a Twist," twisted amides are not that unusual and are indeed naturally occurring in some of nature's most interesting molecules, proteins (C&EN, June 12, page 9).
A detailed structural analysis of some snake venom proteins has revealed that some do have twisted amide linkages in them. These results emerged from an undergraduate research project and alluded to the potential biochemical significance (ease of hydrolysis) of these reactive sites. (J. Mol. Struct. 2000, 520, 229)
Our work was not extended to proteins other than those examined in that paper, but there is no logical reason why these twisted amide linkages should not be present in other proteins.
Vernon G. S. Box
New York City
You might also like...
The power is now in your (nitrile gloved) hands
Sign up for a free account to get more articles. Or choose the ACS option that’s right for you.
Already have an ACS ID? Log in
Join the conversation
Contact the reporter
Submit a Letter to the Editor for publication
Engage with us on Twitter