Pushing the Frontiers of Mass Spectrometry
To remain competitive against other technologies, mass spectrometry (MS) needs to rise to the challenge of unprecedented throughput with very deep analyses of very complex samples. With analysis time reduced to several minutes by fast liquid separations, confident identification and quantitation over many orders of dynamic range still requires a generational leap in the sequencing performance of MS. The Thermo Scientific™ Astral™ analyzer is a novel class of high-resolution accurate-mass analyzer that compliments the Thermo Scientific™ Orbitrap™ analyzer to provide high speed and sensitivity measurements.
This webinar will explore the underlying technology of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer and its’ application to biomedical research. Rethink what is possible with a mass spectrometer including the analysis of 300 proteomics samples per day, measuring 5,000 proteins from a true single-cell, and collecting fragmentation data on over 90% of compounds in metabolomics experiments.
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Ann Thayer, Contributing Editor, C&EN Media Group
Learn about the novel technology of the Orbitrap Astral mass spectrometer , Understand the benefits of the Orbitrap Astral mass spectrometer , How to apply the Orbitrap Astral mass spectrometer to solve biological questions
Academic Researchers , R&D Scientists , Lab Technicians, Principal Investigators, Lab Managers
Mastering Tricks for Improving Chromatography in Difficult Samples
Ion chromatography, a crucial method for separating and quantifying ionic components, faces complexities in diverse sample matrices. To meet stringent analysis standards and ensure IC component longevity, sample pretreatment is essential. Samples with elevated particulate loads, extreme pH, colloids or high cation concentrations jeopardize chromatographic integrity, potentially reducing column lifespan. Considerations extend to IC-incompatible matrices, like those involving organic solvents, and scenarios requiring ultra trace analyses with preconcentration.
While manual methods exist, the revolutionary shift to inline automation for sample preparation promises increased efficiency, throughput, prolonged column lifespan and notable enhancements in data accuracy and reproducibility. Join our upcoming webinar for an insightful exploration led by Sylvia Singh, Ion Chromatography Applications Specialist at Metrohm USA, who will unravel the intricacies and significant benefits of inline sample preparation for analytical processes.
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Melissa O'Meara, Associate Forensic Science Consultant, C&EN Media Group
Learn about the benefits of inline sample preparation for ion chromatography, Discover the types Metrohm inline sample preparation that are available, Gain an understanding of applications that benefit from inline automation, Learn how to choose the best inline sample prep technique for your sample type and laboratory need
Analysts, technicians, chemists who are either currently using or plan to use IC , Lab managers considering automation for their current IC , Students and researchers who may use IC
Mastering UPW Quality with Real-Time Trace Ion Detection
Ultrapure water (UPW) is crucial for the production of superior-quality semiconductors, but ensuring final product quality can be a challenge without the right tools. UPW undergoes extensive and costly purification, utilizing various physical and chemical treatments to meet increasingly rigorous purity standards. In the face of global water shortages, efficient UPW production is essential. Water recycling facilities at semiconductor plants are tasked with addressing this concern, regenerating wastewater back into UPW. However, the integrity of regenerated UPW must be verified to ensure final product quality. This is where online ion chromatography provides a novel advantage: detecting trace anions, cations, and silica contaminants in real-time down to parts-per-trillion levels.
Join us for a conversation with two industry experts: Ben Greenwood, Senior Manager at Micron Technology's Chemistry Lab, and Dariana Martinez, Product Application Specialist at Metrohm USA. Together, they will delve into the pressing water challenges currently faced by the semiconductor industry. Additionally, they will shed light on the pivotal role of ultrapure water and the significance of real-time ion chromatography to ensure quality control.
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Melissa O'Meara, Associate Forensic Science Consultant, C&EN Media Group
Understand the pivotal role of ultrapure water (UPW) in semiconductor manufacturing and its direct impact on product quality and performance. , Gain insights into the scale of water consumption in the semiconductor industry and the pressing challenges faced in meeting increasingly rigorous purity standards. , Discuss the advanced analytical capabilities of online ion chromatography, and learn how it accurately measures anions, cations, and silica contaminants to verify UPW purity.
Anyone interested in leveraging automation for process optimization and near-real-time data analytics, Process engineers and plant operators responsible for analytical testing and QA/QC Managers responsible for ensuring maximum product quality, Those involved in adopting or implementing Industry 4.0 initiatives and/or focused on developing newer, more efficient manufacturing processes
Direct Analysis of Glycosylated Therapeutics
Glycosylation plays a crucial role in determining the pharmacological properties of biotherapeutics. The molecular heterogeneity of glycosylated biotherapeutics makes it difficult to provide thorough characterization of intact glycoproteins by mass spectrometry. Current methods for analyzing biotherapeutics only measure fragments of the compound or rely on partial digestion of the glycans to reduce sample complexity. These limitations pose important risks and challenges for biotechnology companies that need to report human-compatible and consistent glycosylation, critical for drug safety and efficacy.
We will present a new approach to glycoform fingerprinting that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact glycoproteins by mass spectrometry. The method provides a detailed landscape of the intact molecular weights present in biotherapeutic protein preparations in a single experiment and offers insights into glycoform composition when coupled with a suitable bioinformatic strategy. In addition, we highlight the application of charge detection native mass spectrometry (Direct Mass Technology mode) towards the elucidation of masses and aggregation of heterogeneous glycosylated biotherapeutics.
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Ann Thayer, Contributing Editor, C&EN Media Group
How to elucidate masses from heterogeneous glycosylated biotheraputics , Learn how proton transfer charge reduction (PTCR) can simplify complex protein mixtures , Learn when to use PTCR based methods compared to Direct Mass Technology mode for analysis of biotherapeutics
Laboratory Managers , Biopharmaceutical Researchers , Protein Scientists
Exploring Methods for Antioxidants, Oil and Condition Monitoring in Tribology
Effective oil and condition monitoring enables proactive maintenance strategies and minimizes unexpected failures of machinery such as turbines. By closely monitoring the condition of lubricating oils, maintenance professionals can reduce downtime, extend equipment lifespan and identify potential issues before they escalate. Antioxidants are often added to mitigate these issues, which makes monitoring these chemicals critical for equipment performance.
Join Paul Swan, Technical Manager, APAC at ALS Tribology, and Larry Tucker, Director of Norms and Standards at Metrohm USA, as they discuss vital aspects of oil and condition monitoring and the importance of antioxidants in tribology. Gain valuable knowledge on ASTM methods and discover the latest insights into improvements being made in these areas.
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Melissa O'Meara, Associate Forensic Science Consultant, C&EN Media Group
Importance of antioxidants in lubricants and their impact on equipment performance, How to use voltammetry as a tool to monitor remaining useful life on antioxidants in lubricating oils, Importance of oil analysis in predictive maintenance strategies, Understanding the significance of condition monitoring in preventing unexpected failures, Insights into developments aimed at refining ASTM methods
Anyone currently monitoring remaining useful life of antioxidants in lubricating oils, Anyone using ASTM methods for oil and condition monitoring, Laboratories, equipment manufacturers, oil and additive producers and electric utilities looking to monitor oil conditioning and antioxidant levels in use
The Changing PFAS Landscape: Insights Into EPA Draft Method 1621
EPA Draft Method 1621 represents a shift in thinking in how we screen for PFAS and other fluorinated compounds in the environment, giving a better picture of the full scope of contamination. The method uses combustion ion chromatography (CIC) to determine adsorbable organic fluorine (AOF) in water samples, a non-targeted sum parameter defined by the method itself.
In this webinar, Amelia Paolantonio, from Enthalpy Analytical, will show attendees how she was able to successfully implement this method in her lab. Webinar participants will gain valuable insights into best practices for the method and things to watch out for, such as the importance of cleanliness. Dr. Jay Gandhi, from Metrohm USA, will discuss how to execute a total solution for your fluorine analysis to help you comply with Draft Method 1621.
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Catherine Dold, Health & Environment Writer, C&EN Media Group
Learn about EPA Draft Method 1621 and its requirements, Find out the challenges of executing this method and the strategies to overcome them, Learn how to implement a total solution for complying with the method
Environmental lab technicians, analysts, lab managers, and lab directors, Those interested in learning about new monitoring technologies for PFAS and fluorinated compounds
The Predict-First Paradigm: How Digital Chemistry is Changing Drug Discovery
Drug discovery chemists often ask two common questions: “What is the most efficient way to test my hypothesis?” and “How can I iterate on my ideas quickly?”
Digital chemistry offers a modern paradigm for answering these questions by enabling rapid in silico testing of design ideas using highly accurate digital assays of key properties, accessible across whole project teams. This shift from design strategies based largely on experimental trial and error towards a ‘predict-first’ approach to drug discovery allows teams to dramatically expand the pool of molecules that can be explored and results in a highly interactive and fully in silico design-make-test-analyze (DMTA) cycle. Chemists are empowered to test hypotheses through predictive modeling and iteratively improve designs prior to compound synthesis. Teams can confidently spend time and energy exploring new, unknown, and often more complex designs while sending only the top performing molecules for synthesis.
In this webinar, we will walk through the digital chemistry strategy used by Schrödinger’s Therapeutics Group, which has led to several successful clinical-stage drug candidates. We will demonstrate how this strategy is based in LiveDesign, Schrödinger’s cloud-native, collaborative enterprise informatics platform, which empowers teams to design, computationally assess, and prioritize new compounds together in real-time.
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Catherine Dold, Health & Environment Writer, C&EN Media Group
Predict properties: Understand how computationally-guided molecular design and a predict-first strategy can accelerate and improve your small molecule drug discovery process , Centralize technology: See how Schrödinger scientists used a digital chemistry platform to enhance crowdsourced ideation and team collaboration, Overcome collaboration hurdles: Learn how a centralized platform for molecular design and discovery can increase project efficiency by securely and easily sharing data with internal and external CRO partners
Medicinal Chemists , Synthetic Chemists , Computational Chemists, Digitization Managers , Research IT, R&D Leadership
Have You Got the Chromatography Tools You Need for Polymer Analysis?
GPC/SEC is the go-to technique for determining the molecular weight distribution of synthetic and natural polymers and for comparing batch to batch quality. Specific criteria should be considered when developing or optimizing your method to ensure the success of the application:
- Why determining molecular weight is important
- Key parameters for solvent and column selection
- Column type options, their features, and benefits
- Importance of polymer standards selection and calibrating
- Modes of Detection and expanding the information for your polymer
Practical steps, helpful product information, and application examples will be provided to assist you with selecting the best GPC/SEC solution for your polymer sample.
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Jeff Huber, Technical Contributing Editor, C&EN Media Group
How to select the best GPC/SEC solution for your polymer sample , Learn practical tips and tricks to optimize your GPC/SEC workflow, Best practices for polymer analysis
Chromatographers interested in polymer analysis
Optimizing Optics Using Advanced Spectrophotometry
This webinar will guide you on the best practices, tools, and techniques needed to get the most reliable, verifiable insights into your optical components. Appropriate choice of technique and methodology is critical to getting the information you need to improve design, verify product performance, and accelerate manufacturing.
We will explore the subtleties of reflection and transmission measurements at normal incidence and at oblique angles, emphasizing high absorbance, optical density, linearity, and effects of incident beam collimation. We will discuss diffuse scattering measurements and automation/robotics to broaden quality assurance programs and speed up analysis.
The webinar is relevant to developers of optics, photonics, and electro-optical or semiconductor devices such as visual displays, laser-based range detection (LiDAR), optical communications systems and light-based scientific instrumentation. Improve your understanding of the link between your desired outcomes and the spectrophotometric approaches needed to achieve those insights.
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Catherine Dold, Health & Environment Writer, C&EN Media Group
The best spectrophotometric practices to extract deeper insights into the characteristics of optical samples. , How to overcome the limitations of traditional spectrophotometric tools and verify outcomes. , Accelerating QA/QC of optics in a production environment.
Commercial or Academic organizations in the fields of optics, photonics, electro-optical, or semiconductors, Laboratory Managers , Scientist/Staff Scientists, Lab Technician/Technologist, Analyst, Project Manager, SME Directors, Core Lab/ Facility Managers , Under/Post Graduate Researchers
Optimize Your Process Control of Olefin Isomerization
Optimizing olefin isomerization typically involves time-consuming testing of both intermediate and final product. The unavoidable delay between sampling and process changes using traditional chromatographic methods fails to eliminate the need for post-production adjustments and can even result in batch loss.
In this webinar, Tiffany Adkins, Quality Manager at Aurorium, will explain how fast, specific Raman spectroscopy improved her manufacturing quality and reduces product loss. She will discuss her phased implementation approach to Raman and lessons learned, the simplicity of quantitative method development and future use cases for the technique.
Elena Hagemann, Metrohm USA Spectroscopy Product Specialist, will give an overview of Raman spectroscopy and explain how the fundamentals of this technique make it well-suited for specialty chemicals and formulated products.
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Kelly McSweeney, Contributing Editor, C&EN Media Group
Discover how Raman spectroscopy gives quicker results than most other analytical technologies, leading to better response time to process variations, Gain understanding on how Raman spectroscopy can be utilized to quantify the isomerization content in olefins via the variation in present double bonds, Learn about overcoming implementation challenges in Raman Spectroscopy by showcasing different challenges, the approach to find solutions and the key learnings that will ease the implementation of Raman spectroscopy
Those in the chemical industry, both specialty chemical and final product manufacturers looking to increase production quality and efficiency, Production and QA managers of all industries seeking solutions to get actionable data faster, Product development chemists seeking to design products for quality and manufacturability, Researchers looking for Raman measurement solutions for a variety of materials, Process development engineers and scientists looking for upstream/development solutions that can scale with production
Achieving the Pesticide MRLs with GC/MS/MS Using Hydrogen Carrier Gas
Recurring helium shortages and increased prices boost the demand for performing GC/MS analysis with alternative carrier gasses. While helium is the best carrier gas for GC/MS, hydrogen is the second-best alternative. However, unlike helium, hydrogen is not an inert gas. Hence, it can cause peak tailing, distorted ion ratios in the mass spectrum, poor library matching, and sensitivity loss.
Pesticides analysis can be challenging even with helium carrier gas given their diverse and labile nature. This presentation discusses the key strategies for analyzing pesticides with hydrogen carrier gas while delivering high-quality uncompromised results. To achieve the required detection limits with hydrogen carrier gas, the injection conditions were optimized. Further, the EI source optimized for use with hydrogen carrier gas allowed for preventing undesirable in-source reactions. Finally, method translation, and retention time locking techniques allowed the use of the MRM transitions and retention times from the database created with helium carrier gas.
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Melissa O'Meara, Associate Forensic Science Consultant, C&EN Media Group
Optimization of GC conditions essential when using hydrogen carrier gas , Appropriate MS hardware selection, including the EI source optimized for use with hydrogen carrier gas , Method translation technique for maintaining the same retention times as the original method with helium carrier gas or to scale the analysis speed with accurate retention time prediction
Laboratory Managers , Chromatographers, New Product Developers
Accelerating the Design of Asymmetric Catalysts with a Digital Chemistry Platform
Asymmetric catalysis has become an integral part of the science-driven technological revolution in the second half of the 21st century, leading to decreased energy demands, sustainable chemical processes and the realization of “impossible” transformations. Asymmetric catalysis based on chiral transition-metal complexes plays an important role in the synthesis of single-enantiomer drugs, perfumes and agrochemicals. The importance of the field is recognized by two Nobel Prize Awards in 2001 (transition-metal catalysis) and 2021 (organocatalysis).
Asymmetric catalysts are traditionally designed by experimental trial-and-error methods, which are resource-, time- and labor-consuming, and thus extremely expensive. Digital methods offer the opportunity to expedite catalyst design. Until recently, computational chemistry, typically quantum chemical studies, indirectly contributed to asymmetric catalyst design by providing rationalization for the mechanism of generation of chirality. With the development of more advanced methods, algorithms and an included layer of automation, computational catalysis is now providing the possibility for direct asymmetric catalyst design.
In this webinar, we will demonstrate how Schrödinger’s advanced digital chemistry platform can be used to accelerate the direct design and discovery of asymmetric catalysts.
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Melissa O'Meara, Associate Forensic Science Consultant, C&EN Media Group
Learn how to design an asymmetric catalyst with computational chemistry, Learn how automated high-throughput simulation workflows enable rapid asymmetric catalyst design, Understand the intersection of physics-based and machine learning techniques in asymmetric catalyst design
Synthetic Chemists, Materials Scientists, Chemical Engineers, Digitization Managers, R&D Scientists Designing Novel Catalysts