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Proteomics

Protein sequences decoded from extremely old mammal teeth

2 new studies of enamel from rhino and elephant ancestors could help answer evolutionary questions that DNA can’t


Microsoft AI predicts protein conformations

The open-source tool goes beyond AlphaFold by finding proteins’ multiple equilibrium states and free energies

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Medicinal Chemistry

Atom-swapped morphine may help create safer painkillers

By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory depression in mice


Skeletal editing: How close are we to true cut-and-paste chemistry?

Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll fundamentally change how molecules are made