Targeted protein degraders are redefining how small molecules look and act

The new modality promises to open up the human proteome to drug developers, but first they will need to work out the rules

Vaccines against addictive drugs push forward despite past failures

Vaccines could help prevent relapses but have yet to be effective in clinical trials

Periodic graphics: The chemistry of air fresheners

Chemical educator and Compound Interest blogger Andy Brunning sniffs out an answer to the question of whether air fresheners actually ‘kill’ bad odors

Why the end of the world’s most popular coffee could be nigh

Without a fix, climate change and disease are poised to kill off the most prized variety

Genetic screen of soil microbes uncovers novel antibiotics

Method could help researchers discover new natural products from hard-to-culture microorganisms

Chemjobber on when it’s time to leave a bad job

When you’ve lost your voice and loyalties have run dry, it’s time to quit

Trump’s 2019 spending plan scares science supporters

Environment and energy programs face major cuts, basic science is mostly spared

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C&EN is helping coordinate a symposium at the ACS National Meeting to continue the discussion of sexual harassment in chemistry. In this promo for our new podcast, Stereo Chemistry, we talked with C&EN’s Linda Wang to learn what we can expect from that event. We’ll talk more about this issue in an upcoming episode of Stereo Chemistry, which launches on Feb. 28. Subscribe now on iTunes so you don’t miss an episode.

CHEMISTRY IN PICTURES

This is what a mood ring might look like if it exploded on your lab bench. Read more at C&EN ChemPics.