The first examples of Suzuki-type cross-coupling involving perfluorinated arenes have been reported by Udo Radius and his coworkers at Karlsruhe University, in Germany (J. Am. Chem. Soc. 2006, 128, 15964). Chemists have taken a great interest in C-F bond activation reactions in part to synthesize fluorinated drug analogs. The very strong C-F bond helps modulate the lipophilicity of a drug to improve its bioavailability and helps control drug metabolism. So far, most cross-coupling reactions have involved converting monofluorinated arenes into nonfluorinated derivatives, while fluorinated arene products have remained elusive. Radius' group has developed a nickel catalyst, stabilized by N-heterocyclic carbene ligands, that selectively activates the C-F bond para to the electron-withdrawing CF3 group in perfluorotoluene or C6F5 group in perfluorobiphenyl. The catalyst then mediates coupling of the intermediate with a phenyl or biphenyl boronic acid to form polyfluorinated biphenyl or triphenyl products (one example shown).