Issue Date: May 7, 2007
Zipper Structures Play Key Role In Amyloid Aggregates
Two years ago, David Eisenberg of UCLA and a collaborative international group obtained the first atomic structure of an amyloid fibril formed from a yeast prion protein and found that an interdigitated β-sheet structure called a steric zipper was essential to fibril formation (C&EN, June 13, 2005, page 9). Now, the same group has confirmed that steric zippers are a common structural feature in such aggregates by determining the atomic structures of microcrystals . . .
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