Volume 85 Issue 22 | p. 31 | Concentrates
Issue Date: May 28, 2007

Dendrimer Cleaves Cooperatively

Department: Science & Technology

The functional units of enzymes often cooperate with each other to carry out catalytic tasks efficiently. Chemists in Italy now show that metal complexes dotting the periphery of a dendrimer also can work cooperatively. Paolo Scrimin of the University of Padova and colleagues functionalized a dendrimer with Zn2+-bound triazacyclononane ligands. They found that it cleaves a phosphate diester model of RNA cooperatively, exhibiting a 270-fold rate acceleration compared with the Zn2+-triazacyclononane complex alone and . . .

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