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Analytical Chemistry
The P in HPLC
February 11, 2008
| A version of this story appeared in
Volume 86, Issue 6
N . Leo Benoiton's expression of extreme disappointment (C&EN, Dec. 17, 2007, page 4) concerning the "confusion in terminology" for HPLC in a review of supercritical fluid chromatography (C&EN, Oct. 22, 2007, page 49) versus C&EN's reportedly eloquent instruction by an HPLC expert from Waters Corp. is rather ironic upon further investigation.
Benoiton insists that the HPLC technology was christened "high-performance liquid chromatography" and that the (mis)use of the expression "high-pressure liquid chromatography" is disturbing. Yet the most recent IUPAC "Compendium of Analytical Nomenclature" refers to the technique as "high-performance (or high pressure) liquid chromatography." Furthermore, the Waters Corp. website itself notes that the technique was originally referred to as high-pressure liquid chromatography. There is also a textbook titled "High-Pressure Liquid Chromatography."
Paul J. Karol
Pittsburgh
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