Web Date: June 5, 2008
Ligands Key To Chirality
By relaying chiral information from an amino acid ligand to a palladium catalyst and onward to a substrate, Jin-Quan Yu and colleagues at Scripps Research Institute have selectively functionalized carbon-hydrogen bonds to form optically pure products (Angew. Chem. Int. Ed., DOI: 10.1002/anie.200801030). This finding could reduce the number of steps needed to make molecules, one of the most coveted goals for synthetic chemists.
Activating the relatively inert C–H bond . . .
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