Trubion, Facet Link For Leukemia Drug | September 7, 2009 Issue - Vol. 87 Issue 36 | Chemical & Engineering News
Volume 87 Issue 36 | p. 30 | Concentrates
Issue Date: September 7, 2009

Trubion, Facet Link For Leukemia Drug

Department: Business
Keywords: leukemia, monoclonal antibody, Trubion, Facet

Trubion Pharmaceuticals has partnered with Facet Biotech to commercialize TRU-016, a Trubion product in Phase I clinical trials for the treatment of chronic lymphocytic leukemia. Facet will pay a $20 million up-front fee and buy $10 million in Trubion stock. Trubion could gain another $177 million in milestones as the drug progresses toward the market. TRU-016 is a small modular immunopharmaceutical (SMIP) protein, basically a monoclonal antibody that is one-third to one-half the size of a traditional antibody drug. Trubion uses combinatorial chemistry to assemble SMIPs with a binding domain, a hinge domain, and an effector domain.

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