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Web Date: November 5, 2009

An Enzyme Reveals An Unexpected Inclusiveness

Protein Binding: Bacterial enzyme's active site welcomes both enantiomers of a chiral molecule at the same time
Department: Science & Technology
Keywords: enzymes, proteins, enantiomers, drugs, binding

European researchers have discovered the first enzyme that can simultaneously bind both enantiomers of a chiral molecule in its active site. They believe this behavior could have important implications for drug discovery.

Usually, an enzyme can bind only one enantiomer of a chiral molecule. Rare cases have previously been discovered in which a second enantiomer can also bind to an enzyme's active site, but never at the same time as the first. Now, in work . . .

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Chemical & Engineering News
ISSN 0009-2347
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