ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Analytical Chemistry

Metal Nanoparticles Can Be Used As Universal Probe For Many Imaging Methods

by Celia Henry Arnaud
September 5, 2011 | APPEARED IN VOLUME 89, ISSUE 36

[+]Enlarge
Credit: Courtesy of Jie Zheng
Metal nanoparticles can be used for imaging cancer cells with fluorescence microscopy.
08936-scicon-fluorescencecxd.jpg
Credit: Courtesy of Jie Zheng
Metal nanoparticles can be used for imaging cancer cells with fluorescence microscopy.

A new type of nanoparticle works as a label for five types of microscopy. Different microscopy methods usually require different types of probes, making the resulting images difficult to correlate. Chemistry professor Jie Zheng and graduate student Chen Zhou of the University of Texas, Dallas, reported that metal nanoparticles can be used as universal probes for five types of microscopy—bright field, dark field, fluorescence, Raman, and two-photon excitation. Zheng attributed the particles’ versatility to a structural phenomenon that he called the grain-size effect. “Each individual nanoparticle is composed of many tiny grains,” Zheng said. Those grains have two distinct size distributions within the particles. That structure gives each highly polycrystalline silver nanoparticle its strong and robust single-particle luminescence, Zheng said. His team decorated the nanoparticle’s surface with peptides that bind to integrin receptors on cell surfaces. With the probe, the researchers imaged brain cancer cells at the single-particle level using multiple types of microscopy.

[+]Enlarge
Credit: Courtesy of Jie Zheng
08936-scicon-silverTEM.jpg
Credit: Courtesy of Jie Zheng
X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment