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A complete set of fluorescent RNA nucleoside analogs gives researchers an improved tool for probing biophysical properties of nucleic acids, according to a new study (J. Am. Chem. Soc., DOI: 10.1021/ja206095a). Chemists Yitzhak Tor, Dongwon Shin, and Renatus W. Sinkeldam of the University of California, San Diego, synthesized all four analogs using the same thienopyrimidine core. The researchers obtained the pyrimidine analogs (cytidine analog shown) by adding
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