Volume 89 Issue 51 | p. 37 | Concentrates
Issue Date: December 19, 2011

Cage-Catalyzed Condensation

The Knoevenagel condensation can be carried out in water, thanks to a palladium cage catalyst
Department: Science & Technology
News Channels: Materials SCENE, JACS In C&EN
Keywords: Knoevenagel condensation, cage catalyst, water

With the help of a palladium-based cationic cage, researchers in Japan have coaxed a Knoevenagel condensation to take place under neutral conditions in water (J. Am. Chem. Soc., DOI: 10.1021/ja210068f). Knoevenagel condensations are reversible reactions involving attack of a carbanion of a 1,3-dicarbonyl compound on an aldehyde or a ketone followed by dehydration. It’s tough to do the transformation in water because the solvent pushes the . . .

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