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Web Date: August 11, 2011

Sensing Sugars On Proteins

Glycoprotein Analysis: Raman spectroscopy reveals a protein’s glycosylation state
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: glycosylation, glycoprotein, Raman spectroscopy

When pharmaceutical companies produce protein-based drugs, they must ensure that the proteins have the proper sugar groups attached. A protein’s so-called glycosylation state can change its stability and function, as well as how the immune system reacts to it. Now, for the first time, researchers demonstrate that Raman spectroscopy can differentiate between the native and glycosylated forms of a protein (Anal. Chem., DOI: 10.1021/ac2012009).

A therapeutic antibody with the wrong sugars may lose . . .

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