Volume 90 Issue 22 | p. 47 | Concentrates
Issue Date: May 28, 2012

Pores Expand To Fit Proteins

New metal-organic framework compounds may have drug delivery and other applications
Department: Science & Technology
News Channels: Biological SCENE, Nano SCENE, Materials SCENE
Keywords: metal organic frameworks, biological molecules, pore size, MOFs
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In this artist’s conception, A protein sits inside the pore of a new metal-organic framework.
Credit: Science
An artists rendition of a protein, represented with a ribbon structure, encased in a MOF, represented by a hexagonal pore made of grey, red, and blue balls.
 
In this artist’s conception, A protein sits inside the pore of a new metal-organic framework.
Credit: Science

Researchers have synthesized metal-organic frameworks (MOFs) with pore apertures large enough to house protein molecules, up to 98 Å (Science, DOI 10.1126/sci​ence.1220131). Until now, pores in such materials that are larger than 32 Å have been difficult to achieve. MOFs are already important in industry and engineering for molecule storage and separation. Now, scientists are able to store biological molecules, including large organic molecules and proteins, within these material frameworks, reports an international team including Omar M. Yaghi and Hexiang Deng at UCLA. The group began its synthesis with a well-studied MOF, MOF-74, which contains linkers that have one phenylene ring. They expanded the linker structures by adding two, three, four, five, six, seven, nine, and 11 phenylene rings, which produced a series of isoreticular structures having the same topology as the original MOF-74 but with sequentially larger pores.

 
Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society
Comments
Marziyeh Omidi (Mon Jul 09 09:19:04 EDT 2012)
Hi,
I'm student of chemical engineering,biotechnology in IRAN.My project is about the possibility of NMOFs in protein loaing. I was wondering if you could possibly help me with some information about the possibility of MIL100 and MIL101 and protein loading
thanks

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