AB Sciex' TripleTOF 5600+

AB Sciex introduced a second generation of its TripleTOF 5600 system. The TripleTOF 5600+ incorporates technology that AB Sciex calls MS/MS^ALL with SWATH acquisition. SWATH acquisition is a method for acquiring quantitative MS/MS data on every component in a sample with a single injection. The technology, which was developed in collaboration with Ruedi Aebersold at ETH Zurich, depends on a combination of high speed, sensitivity, and dynamic range. The ion intensity data are saved in a complete digital archive, which can be mined immediately or retrospectively, meaning that the same sample can be used to answer additional questions without a need to rerun the sample. The system is also compatible with AB Sciex’ SelexION differential ion mobility separation technology. The system’s software has also been improved to support regulatory compliance in the pharmaceutical industry.