Easy Route To Microcapsules | Chemical & Engineering News
Volume 90 Issue 7 | p. 37 | Concentrates
Issue Date: February 13, 2012

Easy Route To Microcapsules

Supramolecular chemistry assembles cargo-carrying hollow spheres from microfluidic droplets
Department: Science & Technology
News Channels: Biological SCENE, Materials SCENE
Keywords: microfluidics, capsules, supramolecular

Researchers at the University of Cambridge have used supramolecular host-guest chemistry to fabricate cargo-carrying microcapsules from microfluidic droplets in a single step (Science, DOI: 10.1126/science.1215416). Oren A. Scherman, Chris Abell, and coworkers chose cucurbit[8]uril as the host molecule because it can form a ternary complex with two guests—in this case, methyl viologen attached to gold nanoparticles and a naphthol-containing copolymer. The researchers combined individual solutions of the three components in a microfluidic device to form a single aqueous phase. The oil phase shears droplets off the aqueous phase at a T junction. As the oil phase carries the droplets through a winding channel, the components combine to form hollow micro­capsules consisting of a dispersion of gold nanoparticles in a polymer mesh held together by cucurbit[8]uril. The size of the microcapsules ranges from 10 to 24 µm and varies with the ratio of the oil and aqueous flow rates. The researchers can load a variety of cargo—such as drugs, biological molecules, and even cells—in the microcapsules by adding a fourth solution to the aqueous phase during fabrication.

Credit: Science
Microcapsules consisting of methyl-viologen-labeled gold nanoparticles in a mesh of a naphthol-containing copolymer (red string) held together by cucurbit[8]uril.
Credit: Science
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