ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Materials

Graphene Envelops Nanoparticles

Nanoparticle Delivery: Simple method yields tiny graphene packets that could hold drugs or imaging agents

by Prachi Patel
April 2, 2012

Tiny Bundles
[+]Enlarge
Credit: Nano Lett.
A thin graphene layer shrouds silver nanoparticles (oblong white shapes) in this scanning electron micrograph.
20120402lnj1-fig2.jpg
Credit: Nano Lett.
A thin graphene layer shrouds silver nanoparticles (oblong white shapes) in this scanning electron micrograph.

A simple technique can swathe nanoparticles with a blanket of graphene (Nano Lett., DOI: 10.1021/nl2045952). The tiny graphene packets could carry medical imaging contrast agents, allowing the nanoparticles to enhance imaging signals while shielding tissue from their potential toxic effects. They could also deliver chemotherapy drugs to tumors, says Brown University’s Robert Hurt, who developed the new nanoparticle sacks.

Other approaches to wrap nanoparticles in graphene require chemically modifying both the particles and graphene to endow them with opposite charges, Hurt says.

Hurt and his colleagues avoided the modification steps by adapting a recently reported aerosol technique for crumpling graphene flakes into wads (ACS Nano, DOI: 10.1021/nn203115u). Using an ultrasonic nebulizer, they make a mist from an aqueous suspension of graphene oxide flakes and various nanoparticles—they tested the technique with particles of silver, organic dye molecules, and DNA. Graphene oxide flakes tend to accumulate at the droplet surface. When the droplets pass through a furnace, graphene oxide reduces to graphene. As water evaporates and the droplets shrink, the graphene flakes collapse to form sacks around a few nanoparticles. A filter captures the packets.

The technique is much easier than previous graphene wrapping methods, and gives discrete, uniformly coated particles, Hurt says. Because it relies on “physically forcing things together” rather than electrostatic attraction, he says, a much wider range of materials are amenable to wrapping.

For drug-delivery applications, the team is now trying to understand if and when the packets open and release their contents, and whether the release time can be tuned. “We know they go into cells,” says Hurt, “but will they deliver?”

Advertisement
X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment