Volume 91 Issue 36 | p. 24 | Concentrates
Issue Date: September 9, 2013

New Route To On-Off Gene Control

RNA-guided system turns genes both on and off in cells, providing new options for studying protein expression and developing disease therapies
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: CRISPR, Cas9, gene expression

A bacterial immune system component called CRISPR/Cas9 has been widely adopted in the past year for modifying genes and turning them on or off to study gene expression and develop new therapies. Timothy K. Lu and coworkers at MIT have now succeeded in both activating and repressing genes with the same Cas9 construct, just slightly modified by a customized guide RNA in each case to hit a different spot on a . . .

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