Volume 91 Issue 37 | p. 9 | News of The Week
Issue Date: September 16, 2013

Key HIV Entry Point Analyzed

Structural Biology: Long-sought structure of CCR5 cell receptor could improve drugs that block the virus
Department: Science & Technology
News Channels: Organic SCENE
Keywords: CCR5, HIV, AIDS, HIV inhibitor

For the first time, the structure of the receptor that is the predominant entry point for the AIDS virus to invade human cells has been determined. Knowing the form of the receptor, called CCR5, raises hopes for the discovery of drugs that can block human immunodeficiency virus more effectively than can the drug maraviroc.

When HIV infects someone, it first interacts with CD4 receptors on immune-cell surfaces. This interaction opens the door for a secondary . . .

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