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Pharmaceuticals

GSK, Vanderbilt Team For Obesity Drug

by Lisa M. Jarvis
February 18, 2013 | A version of this story appeared in Volume 91, Issue 7
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Credit: Joe Howell/Vanderbilt
From left: Cone, lab manager Savannah Williams, and postdoc Julien Sebag in Vanderbilt’s high-throughput screening area.
This is a photo of the Vanderbilt high-throughput screening team.
Credit: Joe Howell/Vanderbilt
From left: Cone, lab manager Savannah Williams, and postdoc Julien Sebag in Vanderbilt’s high-throughput screening area.

GlaxoSmithKline and Vanderbilt University will work together to develop drugs to treat severe obesity. Led by biologist Roger Cone, Vanderbilt scientists have discovered positive allosteric modulators of melanocortin-4 receptor (MC4-R), a protein involved in body weight regulation. In exchange for access to the MC4-R modulators, GSK will provide Vanderbilt with three years of research support as well as milestone payments on any drug candidates developed. The partners hope to have an MC4-R modulator in Phase I studies by 2016.

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