Study Suggests Mechanism For How Eye Protein Protects Against Cataracts | Chemical & Engineering News
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Web Date: December 22, 2014

Study Suggests Mechanism For How Eye Protein Protects Against Cataracts

Structural Biology: NMR study of protein fragment reveals how chaperone might scan for unfolded regions in eye protein it protects
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: crystallin, cataract, lens, eye, protein folding, protein misfolding, aggregation

A new study reveals the likely mechanism that a protein called human α-crystallin uses to protect the lens of the eye from clouding or becoming opaque. The work could lead to new drugs to prevent cataract formation.

The human eye lens contains a protein called γD-crystallin that can unfold, oxidize, and aggregate to form cataracts. Human α-crystallin protects the lens by inhibiting γD-crystallin aggregation.

But how this so-called chaperone protein works on a molecular level . . .

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