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Pharmaceuticals

Bayer Licenses Drug From Isis Pharma

by Ann M. Thayer
May 11, 2015 | A version of this story appeared in Volume 93, Issue 19
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Bayer HealthCare will pay Isis Pharmaceuticals up to $155 million to develop and commercialize ISIS-FXIRx for the prevention of thrombosis, or clotting disorders. Isis will receive $100 million up front and the rest if the drug advances following a Phase II study in patients with compromised kidney function. ISIS-FXIRx is an antisense drug that inhibits the production of Factor XI, a clotting factor produced in the liver. Bayer also plans to evaluate ISIS-FXIRx in patients for whom current anticoagulants cannot be used.

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