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Roche has agreed to pay $140 million up front and up to $400 million more in milestone payments to acquire Trophos, a biotech firm based in Marseille, France. Along with venture capitalists, investors in the 16-year-old company have included the French Muscular Dystrophy Association. Trophos specializes in cholesterol-oxime chemistry. Designed to protect motor nerve cells, its lead compound, olesoxime, is in Phase II clinical trials against spinal muscular atrophy, a rare genetic disease. U.S. and European regulators have given orphan drug designation to olesoxime.
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