Tramadol is contaminant, not natural product | Chemical & Engineering News
Volume 93 Issue 44 | p. 26 | Concentrates
Issue Date: November 9, 2015

Tramadol Is Contaminant, Not Natural Product

Environmental Chemistry: Study confirms that opiate found in environment is synthetic
Department: Science & Technology
News Channels: Analytical SCENE, Environmental SCENE, Biological SCENE
Keywords: tramadol, natural product, contamination, Cameroon

A study confirms that the opiate tramadol recently found in trees is not a natural product, as controversially suggested in the past, but is instead human contamination (Angew. Chem. Int. Ed. 2015, DOI: 10.1002/anie.201508646). Chemists were surprised by the discovery of tramadol, which is a synthetic compound, in Sarcocephalus latifolius, a tree native to Cameroon and neighboring countries. The results suggested that tramadol might be a newly discovered natural product and added to the list of opiates produced by plants (Angew. Chem. Int. Ed. 2013, DOI: 10.1002/anie.201305697). However, Michael Spiteller of the Technical University of Dortmund and colleagues argued that farmers, who feed tramadol to cattle to help them tolerate extreme heat, released the compound into the environment (Angew. Chem. Int. Ed. 2014, DOI: 10.1002/anie.201406639). Now, Spiteller’s team reports the final nail in the coffin: The tramadol molecules from environmental samples contain no 14C. The abundance of 14C and other isotopes in molecules produced by living plants should match that of Earth’s atmosphere. The complete absence of 14C proves that the molecules are synthetic, the authors say.

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