ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Synthesis

Dual C–F/C–H functionalization unveiled

Iridium photocatalyst enables coupling of two unactivated aryl partners to create complex multifluorinated biaryl compounds

by Stephen K. Ritter
March 7, 2016 | APPEARED IN VOLUME 94, ISSUE 10

In an effort to develop a general method for making multifluorinated biaryl compounds, a pair of chemists has achieved the first example of a direct cross-coupling reaction between a C–F bond of one aryl compound and a C–H bond of another aryl compound without having to first prefunctionalize either of the aryl coupling partners like in traditional cross-coupling strategies (J. Am. Chem. Soc. 2016, DOI: 10.1021/jacs.5b13450). Sameera Senaweera and Jimmie D. Weaver of Oklahoma State University, Stillwater, previously determined how to use an iridium photocatalyst with amine reductant to selectively functionalize a C–F bond of multifluorinated aryl compounds. Along the way they realized there was an opportunity to go further with the perfluoroaryl radical intermediate and use it to couple with a nonfluorinated aryl partner if they could create the right reaction conditions. Starting from pentafluoropyridine, they found that the iridium catalyst with a bulky amine under blue LED light works, leading to a wide array of multifluorinated biaryl compounds (one example shown) that are typically useful in drugs, agrochemicals, and electronic materials. “We believe that, even though some of the yields are modest, the fact the reaction takes place in a single step from two broadly available partners and tolerates a broad range of functionality really gives this method legs,” Weaver says.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment