Infinity cuts drug discovery operations | June 20, 2016 Issue - Vol. 94 Issue 25 | Chemical & Engineering News
Volume 94 Issue 25 | p. 11 | News of The Week
Issue Date: June 20, 2016 | Web Date: June 16, 2016

Infinity cuts drug discovery operations

Decision comes after a failed clinical trial for the PI3K inhibitor duvelisib
Department: Business
Keywords: pharmaceuticals, biotech, oncology, PI3K

Following yet another clinical setback, Infinity Pharmaceuticals is shutting down its discovery activities. The decision will affect 46 researchers, or 21% of the Cambridge, Mass.-based firm’s workforce. Its stock price tumbled by nearly 70% last week.

The restructuring comes after disappointing results for a Phase II study of the firm’s dual PI3K inhibitor duvelisib in non-Hodgkin lymphoma. The drug candidate, which is being tested in a variety of blood cancers, elicited a 46% partial response in people with a slow-growing type of NHL. That’s far below the 65% response rate stock analysts say the drug would need to compete with Gilead Sciences’ PI3K inhibitor Zydelig, which itself is far from a commercial success.

Infinity’s PI3K program has gone through several partnerships. Originally licensed to Purdue Pharmaceuticals in 2008 as part of a broader drug development pact, the program was returned to Infinity in 2012. Two years later, AbbVie paid $275 million upfront for the right to jointly develop duvelisib.

The failed trial prompted the partners to pause a study that combines the PI3K inhibitor with AbbVie’s Bcl-2 inhibitor Venclexta. They say they are “exploring next steps” for their collaboration.

RBC Capital Markets stock analyst Michael Yee told investors that AbbVie “is unlikely to move forward, and Infinity will need to find a new partner to get the drug across the goal line.” Moreover, Yee estimates Infinity is spending about $30 million per quarter and will need to raise money in the next year.

This is the latest bump in the road for Infinity. Although R&D chief Julian Adams is well known as a gifted drug hunter—prior to arriving at Infinity he was behind the development of the successful proteasome inhibitor Velcade—the company has failed to get any products across the finish line. High profile partners have come and gone for small molecules that block tough targets, including the hedgehog pathway, heat shock protein 90, and fatty acid amide hydrolase. None of those programs succeeded in the clinic.

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Wojtex (June 17, 2016 5:03 PM)
In my humble opinion the structure should be changed.
1. Changing CH in position 4 of isoquinolinone to nitrogen atom.
2. Chang. of oxygen to =NH
The new compounds is a derivative of quinazolin-4(3H)-imine. It should be reinvestigated.
3. Dimroth rearrangement of the last one should give a derivative of 4-phenylaminoquinazoline - the second compound to new anticancer tests.

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