Given simple text prompts, an artificial intelligence-driven system can plan and execute difficult chemical reactions (Nature 2023, DOI: 10.1038/s41586-023-06792-0). The system could ease communication between humans and AI systems to speed up scientific research.
Dubbed Coscientist, the system uses the language model behind the chatbot ChatGPT. With a prompt such as “perform multiple Suzuki reactions”, the AI browses the internet to learn about the reactions, scours relevant literature and hardware documentation for information, and in minutes, outlines the procedures necessary to perform these reactions. It then writes a code, which a robot uses to run the experiment.
“We are converting bits to atoms,” says Gabe Gomes, a chemist and chemical engineer at Carnegie Mellon University, in a press briefing. “Taking a natural language prompt, the bits, and converting it into an actual chemical reaction.”
Coscientist could successfully perform the complex Nobel Prize-winning palladium-catalyzed cross coupling reaction named after Akira Suzuki with a 50% yield the very first time. It could also accurately plan procedures to synthesize common pharmaceutical compounds such as aspirin and ibuprofen. Gomes says he and his team are fully aware of the potential illicit use of Coscientist and are collaborating with other researchers and policymakers to prevent such misuse.
Tiago Rodrigues, a medicinal chemist at the University of Lisbon, says that Coscientist fills the important gap of communication necessary to meet the long-standing goal of self-driving labs. AI chemists such as Coscientist and ChemCrow, which was recently developed by another research team, could enable the full automation of the design-make-test cycle, he says. “This can have tremendous impact in terms of productivity since researchers can dedicate their time to other tasks.”