ERROR 1
ERROR 1
ERROR 2
ERROR 2
ERROR 2
ERROR 2
ERROR 2
Password and Confirm password must match.
If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)
ERROR 2
ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.
On May 8, CAS registered its 150 millionth unique chemical substance—a 2-pyrimidinamine carbonitrile derivative, one of several promising compounds studied as inhibitors of two kinases (TBK and IKK) implicated in cancer and immunological diseases, including rheumatoid arthritis, systemic lupus erythematosus, and lupus nephritis.
CAS, a division of the American Chemical Society, provides scientific information services such as SciFinder and patent searching.
The substance was disclosed in a Merck KGaA patent reported by the World Intellectual Property Organization. The full name of the compound, CAS Registry Number 2306877-20-1, is 2-[[3,3-difluoro-1-[(2R)-2-hydroxy-1-oxopropyl]-4-piperidinyl]oxy]-5-[2-[[5-[(2R)-2,4-dimethyl-1-piperazinyl]-6-methoxy-2-pyridinyl]amino]-4-pyrimidinyl]benzonitrile.
Gilles Georges, vice president of CAS content operations, says it’s important to celebrate such milestones. “We don’t want it to be just a number; it has significance in terms of where the research is going. It took us about 40 years to register the first 25 million substances, and we reached that in 2005. We have registered 50 million substances in the last 4 years. That really speaks to the acceleration of chemistry research globally.”
The CAS Registry, which identifies and aggregates chemical substance information, was established in 1965. It is now the world’s largest curated database of unique chemical substances.
Join the conversation
Contact the reporter
Submit a Letter to the Editor for publication
Engage with us on X