ADVERTISEMENT
4 /5 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Mass Spectrometry

Mass spectrometry measures chemical exposures in e-cigarette users’ mouths

Small study shows increases in reactive carbonyl compounds, as well as a DNA modification

by Carmen Drahl
August 27, 2018 | APPEARED IN VOLUME 96, ISSUE 34

 

09634-scicon11-structure.jpg

As e-cigarette use skyrockets, so too do studies of their chemistry. The handheld devices generate vapors from nicotine-containing liquids, and most work has focused on the stages of that transformation. Fewer studies have examined the chemistry occurring inside e-cigarette users’ mouths, but Silvia Balbo surmised her team’s mass spectrometry technique could provide insight. The technique analyzes reactive carbonyl compounds appearing in mouths after alcohol exposure, and the glycerol or propylene glycol in e-cigarette liquids generate similar compounds. Balbo and postdoctoral researcher Romel Dator, who presented the work at last week’s ACS national meeting in Boston, recruited five users and collected saliva before and after 15-minute vaping sessions at their University of Minnesota Masonic Cancer Center clinic. After vaping, levels of acrolein and methylglyoxal in users’ saliva increased by as much as 50 times. To examine potential damage by these compounds to DNA, users swished a saline mouthwash to provide oral cells. Compared to nonvaping controls, four of the five users had increased levels of γ-hydroxy-1,N2-propano­deoxyguanosine, an acrolein-DNA adduct. The team next plans to compare e-cigarette users with traditional cigarette smokers. Balbo cautioned that her small study was designed to analyze chemical exposures, not to demonstrate that e-cigarettes cause cancer.

X

Article:

This article has been sent to the following recipient:

Comments
Marie-Josée Creppy (December 7, 2018 11:39 AM)
Thanks

Leave A Comment

*Required to comment