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Indena has commissioned Nerviano Medical Sciences, the largest pharmaceutical R&D facility in Italy, to scale up and produce two drug candidates for preclinical and clinical development. Indena, which specializes in plant extracts, derived the molecules from plants and worked out a semisynthetic path for them. One molecule, the thiocolchicine dimer IDN 5404, acts on tumors resistant to cisplatin and topotecan. The second, IDN 5243, is a relaxant for the treatment of muscular skeletal pain.
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