Issue Date: June 16, 2008
Substrate-Targeting Inhibitors Hint At New Drug Discovery Tactic
Biochemists have uncovered how certain small molecules, including nonsteroidal anti-inflammatory drugs such as the ibuprofen analog tarenflurbil, reduce production of a form of amyloid-β peptide, the plaque-forming protein associated with Alzheimer's disease (Nature 2008, 453, 925). In addition to potentially leading to a new family of drugs to combat Alzheimer's and related disorders, the finding suggests a new tactic for general drug-screening efforts. A form of amyloid-β peptide known as Aβ42 is created when the . . .
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