Issue Date: November 17, 2008
Grignard Radical Ensnared
A key radical intermediate in the Grignard reaction, a textbook reaction in organic synthesis, has been trapped and studied for the first time (Angew. Chem. Int. Ed. 2008, 47, 9118). The organomagnesium Grignard reagent generally reacts with a carbonyl compound to form an alcohol. Normally it acts as a nucleophile, but sometimes a radical mechanism is involved. Despite the reaction's broad use, researchers have never observed the presumed intermediate along the radical pathway, a magnesium . . .
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