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Synthesis
Contraceptive Correction
April 20, 2009
| A version of this story appeared in
Volume 87, Issue 16
IN HIS EDITORIAL reviewing the history of oral contraceptives, Rudy Baum inaccurately states that norethindrone was the basis for the first such product (C&EN, Sept. 22, 2008, page 5).
Norethynodrel, not norethindrone, was the basis for the first oral contraceptive. The former substance, together with a small amount of mestranol, was marketed in 1960 by G. D. Searle & Co. under the trade name Enovid. The product based on norethindrone, also containing a small amount of mestranol, was not marketed until three years later, in 1963, by the Ortho Division of Johnson & Johnson under the trade name Ortho Novum.
Raphael Pappo
Elliot Schubert
San Diego
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