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Northfield Laboratories is closing its plant in Mount Prospect, Ill., and laying off its entire staff there, effectively ending its effort to develop a red blood cell substitute. Late last month, the company received a letter from FDA stating that the agency would not approve the product, a chemically modified hemoglobin called PolyHeme. Northfield is one of several firms trying to develop blood substitutes (C&EN, Feb. 23, page 52).
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