Amgen Licenses Diabetes Drugs | December 21, 2009 Issue - Vol. 87 Issue 51 | Chemical & Engineering News
Volume 87 Issue 51 | p. 23 | Concentrates
Issue Date: December 21, 2009

Amgen Licenses Diabetes Drugs

Department: Business
Keywords: Amgen, Array, diabetes, glucokinase

Amgen and Array BioPharma will jointly develop Array’s portfolio of glucokinase activators, including ARRY-403, a small-molecule drug in Phase I development for type-2 diabetes. Array snags a $60 million up-front payment and future milestones. Amgen is also providing funding for a two-year research collaboration aimed at identifying second-generation glucokinase activators. Glucokinase “senses” glucose in the pancreas by catalyzing the phosphorylation of glucose to glucose-6-phosphate, a critical first step in metabolizing sugar. Drugs like ARRY-403 enable the pancreas to better sense glucose, leading to increased insulin production.

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